Neurological evaluation and vital signs except temperature every 15 min for doctor first 2 h at doctor beginning of rtPA infusion, then every 30 min for 6 h, then every 60 min for 16 h total of 24 h Note: Frequency of BP assessments may wish medical be higher if systolic BP stays 180 mm Hg or diastolic BP stays 105 mm Hg. Temperature every 4 h or as required. Treat temperatures >99. 6F with acetaminophen as orderedIn ICU, every hour with neurological checks or more commonly if essential. In non ICU setting, depending on patients situation and neurological tests, at a minimum check neurological assessment and vital signs every 4 hCall doctor if systolic BP >185 or <110 mm Hg; diastolic BP >105 or <60 mm Hg; pulse <50 or >110 per min; respirations >24 per min; temperature >99. 6F; or for worsening of stroke symptoms or other decline in neurological statusCall physician for further treatment in response to doctor and institutional possibilities/checklist: Systolic BP >220 or <110 mm Hg; diastolic BP >120 or <60 mm Hg; pulse <50 or >110 per min; temperature >99.